Researchers used transcriptomic and proteomic methods as well as biochemical analysis to characterize antibodies from oligoclonal immunoglobulin bands (OCB), a multiple sclerosis (MS) biomarker, and found that OCB antibodies and autoantigens from four MS patients, 27-34 years of age, were ubiquitous intracellular proteins not specific to brain tissue, suggesting that rather than mediating direct tissue destruction, OCB might be indicative of a secondary immune response in MS.
↧