The pathogenesis of diabetic encephalopathy may be associated with oxidative stress and apoptosis. Luteolin (3’,4’,5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. The PI3K/Akt is an apoptosis-related extracellular signaling pathway, and plays an important role in the inhibition of apoptosis and promotion of cell survival.
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